Bioinformatics Services

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Bioinformatic Services

Bioinformatics Services

Bioinformatics goes hand-in-hand with the complex data derived from today’s next generation sequencing technologies. Yet, drug hunters rarely have the computer programming capabilities or expertise to achieve accurate, robust, and in-depth analysis of big data. Get the sophisticated bioinformatics services you need to drive discovery and maximize your ROI when you partner with clinical.

Data Solutions for Bioinformatic Services

By partnering with Fios Genomics we provide a range of bioinformatics services to support pre-clinical and clinical development. These services include:

Single-Cell Analysis

Gene Expression Analysis

Genetic Variation

Proteomics Analysis

Metabolomics Analysis

Epigenetics Analysis

Single-Cell Data Analysis

Single cell RNA sequencing data analysis can help classify which cells are present in a sample and if they differ in terms of expression. Generally, this is done following dimension reduction and clustering using UMAP or tSNE methods. For multiple samples, single cell RNA sequencing facilitates comparisons of expression between equivalent cell types of different samples to measure the effect of a condition or treatment. It also facilitates comparisons of cell type composition of samples from multiple individuals to show the variation of cellular composition at a population scale. By partnering with Fios Genomics for bioinformatics services, we can offer you single-cell gene expression data analysis.

Gene Expression Analysis

We provide gene expression data analysis across platforms like NanoString, CRISPR knockout, and bulk RNA-seq. Our services cover mRNA, miRNA, and small RNAs. We accept various data formats including FastQ, BAM/SAM, count matrices (FPKM/TPM), and platform-specific files such as NanoString RCC and array CEL files from Illumina, Agilent, and Affymetrix.

Genetic Variation Analysis

SNP arrays, Whole Genome Sequencing (WGS), and Whole Exome Sequencing (WES) enable large-scale genetic analysis across the genome. However, the data volume can be substantial and complex. In partnership with Fios Genomics, we offer scalable workflows and cloud-based computing to efficiently process and analyze array-based and next-generation sequencing (NGS) data.

Proteomics Data Analysis

Proteomics helps identify the location, production rate, and degradation of proteins at a given time. It also allows analysis of post-translational modifications (PTMs), protein interactions, and movement between subcellular compartments. By comparing different samples, proteomics can reveal changes in protein abundance, modifications, location, and binding specificity across tissues, treatments, or experimental conditions.

These bioinformatics services include:

Identification of associations between technical and biological variables in the study, via sample metadata assessment
Quality control of the data
Normalization of data across samples
Identification batch-related effects and their correction
Exploratory analysis and evaluation of all types of data
Differential abundance analysis
Functional enrichment analysis

Metabolomics Data Analysis

Metabolomics captures cellular biochemical activity and links genetics, environment, microbiome, and physiology to disease.

We can offer you:

Epigenetics Data Analysis

We offer a range of epigenetics by bioinformatics services including DNA methylation analysis and chromatin immunoprecipitation sequencing (ChIP-seq) analysis.

Epigenetic analyses are relevant to:

Integrated Bioinformatics Services and Specificity Screening

Integrating bioinformatic analysis with off-target/specificity screening creates a powerful filtering system which can be deployed in early discovery with a rapid lead time. Working in combination, these technologies can provide a comprehensive upfront understanding of which candidates show viable specificity to move forward through further studies, including a detailed package of information to enable informed study choices and data-driven downstream study design.

Therapeutic Areas for Bioinformatic Analysis

Fios Genomics offers different data analysis approaches for discovery, characterization and validation of genomic (RNA and DNA) and proteomic biomarkers for a variety of disease areas. Bioinformatics services can help with drug target identification and validation for oncology, GI and microbiome, cardiovascular and metabolic diseases, infections and vaccines, respiratory and dermatology research areas. Applications of bioinformatics services include human medicine, crop studies and nutrition, forensic analysis, and veterinary science.

Join Us in Transforming Healthcare

We invite you to be a part of the healthcare revolution. Collaborate with us to drive innovation, improve patient outcomes, and shape the future of healthcare. Together, let’s make a difference in the lives of millions.